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Reserch & Manufacturing

We conduct feasibility studies, formulation, development, manufacturing, characterization and quality control of liposomal products containing the most complex compounds.

Liposome

A liposome is a tiny bubble (vesicle), made of the same material as a cell membrane. Membranes are usually made of phospholipids, which are molecules that have a head group and a tail group. The head is attracted to water, and the tail, which is made of a long hydrocarbon chain, is repelled by water. Liposomes can be composed of naturally-derived phospholipids with mixed lipid chains (phosphatidylcholine and egg phosphatidyletha-nolamine), or of pure surfactant components like DOPE (dioleoylphosphatidylethanolamine). Liposomes, usually but not by definition, contain a core of aqueous solution. The name liposome is derived from two Greek words: lipos’ meaning fat and ‘Soma’ meaning body. A liposome can be formed at a variety of sizes as uni-lamellar or multi-lamellar construction, and its name relates to its structural building blocks, phospholipids, and not to its size.

Niosome

A Niosome is a Non-IOnic Surfactant-based vesicle, they are formed mostly by non-ionic surfactant and cholesterol incorporation as an excipient. Other excipients can also be used. Niosomes are structurally similar to liposomes.

Benefits

The benefits include the protection of the molecule against degradation, once in the systemic circulation; a better stability which is crucial for thermoliable molecules or molecules sensible to pH and osmotic gradients; better delivery and targeting in key organs and tissues; better bioavailability and absorption than molecules without liposomes niosomes coating; ability to transport lipophilic molecules througout the GI tract and the possibility of particle size reduction, it’s also possible to modulate the release. Niolip will help you to develop a targeted formula to overcome a particle size issue. stability problem, payload concern. absorption and bioavailability need, solubility challenge or to protect your formula from body or other ingredients’ attackers.

Services

Preformulation, formulation, solid state services, molecule analytical chemistry, regulatory consulting.